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Article

Human Epidermal Growth Factor Receptor 2 Alterations and Prognostic Implications in All Subtypes of Breast Cancers.

JCO precision oncology - 1 Jan 2025

Heeke Arielle L, Elliott Andrew, O'Keefe Kaitlyn, Livasy Chad, Symanowski James T, Steiner Meghan R, Kang Irene M, Hoon Dave S B, Walker Philip, Sledge George W, Radovich Milan, Pohlmann Paula R, Swain Sandra M, Tan Antoinette R

Abstract excerpt

PURPOSE: Alterations in human epidermal growth factor receptor 2 (HER2; ERBB2 gene) may be clinically relevant when considering HER2-targeted therapies. We have characterized the breadth of ERBB2 alterations (mutation, fusion, and copy number amplification) in breast cancer and explored the relationship between ERBB2 alterations and prognosis. METHODS: DNA next-generation sequencing (592-gene panel and...

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Aged
Aged, 80 and over
Breast Neoplasms
Erb-b2 Receptor Tyrosine Kinases
ERBB3 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

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Identifiers

PMID: 39889242
DOI: 10.1200/PO.23.00719

Genes

ERBB2
CDH1
ERBB3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Human Epidermal Growth Factor Receptor 2 Alterations and Prognostic Implications in All Subtypes of Breast Cancers.PMID 39889242Read ↗

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