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Article

Removing unwanted variation in a differential methylation analysis of Illumina HumanMethylation450 array data.

Nucleic acids research - 18 Sept 2015

Maksimovic Jovana, Gagnon-Bartsch Johann A, Speed Terence P, Oshlack Alicia

Abstract excerpt

Due to their relatively low-cost per sample and broad, gene-centric coverage of CpGs across the human genome, Illumina's 450k arrays are widely used in large scale differential methylation studies. However, by their very nature, large studies are particularly susceptible to the effects of unwanted variation. The effects of unwanted variation have been extensively documented in gene expression array studies and...

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Identifiers

PMID: 25990733
DOI: 10.1093/nar/gkv526
PMCID: PMC4652745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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