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Revisiting genetic artifacts on DNA methylation microarrays exposes novel biological implications.

Genome biology - 21 Sept 2021

Planterose Jiménez Benjamin, Kayser Manfred, Vidaki Athina

Abstract excerpt

BACKGROUND: Illumina DNA methylation microarrays enable epigenome-wide analysis vastly used for the discovery of novel DNA methylation variation in health and disease. However, the microarrays' probe design cannot fully consider the vast human genetic diversity, leading to genetic artifacts. Distinguishing genuine from artifactual genetic influence is of particular relevance in the study of DNA methylation...

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PMID: 34548083
DOI: 10.1186/s13059-021-02484-y
PMCID: PMC8454075

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