Article
E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient.
The Journal of infectious diseases - 1 Dec 2015
L'Huillier Arnaud G, Abed Yacine, Petty Tom J, Cordey Samuel, Thomas Yves, Bouhy Xavier, Schibler Manuel, Simon Audrey, Chalandon Yves, van Delden Christian, Zdobnov Evgeny, Boquete-Suter Patricia, Boivin Guy, Kaiser Laurent
Abstract excerpt
BACKGROUND: An influenza A(H1N1)pdm09 infection was diagnosed in a hematopoietic stem cell transplant recipient during conditioning regimen. He was treated with oral oseltamivir, later combined with intravenous zanamivir. The H275Y neuraminidase (NA) mutation was first detected, and an E119D NA mutation was identified during zanamivir therapy. METHODS: Recombinant wild-type (WT) E119D and E119D/H275Y A(H1N1)pdm09...
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