Article
Multiple influenza A (H3N2) mutations conferring resistance to neuraminidase inhibitors in a bone marrow transplant recipient.
Antimicrobial agents and chemotherapy - 1 Dec 2014
Eshaghi Alireza, Shalhoub Sarah, Rosenfeld Paul, Li Aimin, Higgins Rachel R, Stogios Peter J, Savchenko Alexei, Bastien Nathalie, Li Yan, Rotstein Coleman, Gubbay Jonathan B
Abstract excerpt
Immunocompromised patients are predisposed to infections caused by influenza virus. Influenza virus may produce considerable morbidity, including protracted illness and prolonged viral shedding in these patients, thus prompting higher doses and prolonged courses of antiviral therapy. This approach may promote the emergence of resistant strains. Characterization of neuraminidase (NA) inhibitor (NAI)-resistant...
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