Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models.

Antiviral research - 1 Aug 2016

Abed Yacine, Bouhy Xavier, L'Huillier Arnaud G, Rhéaume Chantal, Pizzorno Andrés, Retamal Miguel, Fage Clément, Dubé Karen, Joly Marie-Hélène, Beaulieu Edith, Mallett Corey, Kaiser Laurent, Boivin Guy

Abstract excerpt

We recently isolated an influenza A(H1N1)pdm09 E119D/H275Y neuraminidase (NA) variant from an immunocompromised patient who received oseltamivir and zanamivir therapies. This variant demonstrated cross resistance to zanamivir, oseltamivir, peramivir and laninamivir. In this study, the viral fitness of the recombinant wild-type (WT), E119D and E119D/H275Y A(H1N1)pdm09 viruses was evaluated in vitro and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Viral
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guinea Pigs

Share to Influenza A Virus, H1N1 Subtype

Share to Neuraminidase

Share to Orthomyxoviridae Infections

Share to Viral Load

Share to Viral Proteins

Source

Identifiers

PMID: 27185624
DOI: 10.1016/j.antiviral.2016.05.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models.PMID 27185624Read ↗

E119D Neuraminidase Mutation Conferring Pan-Resistance to Neuraminidase Inhibitors in an A(H1N1)pdm09 Isolate From a Stem-Cell Transplant Recipient.Semantic proximity Read ↗

Selection of multi-drug resistant influenza A and B viruses under zanamivir pressure and their replication fitness in ferrets.Semantic proximity Read ↗

Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds.Semantic proximity Read ↗

Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses.Semantic proximity Read ↗

Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient.Semantic proximity Read ↗

Molecular pathway of influenza pan-neuraminidase inhibitors resistance in an immunocompromised patientSemantic proximity Read ↗

Comparison of early and recent influenza A(H1N1)pdm09 isolates harboring or not the H275Y neuraminidase mutation, in vitro and in animal models.Semantic proximity Read ↗

The I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V MutantSemantic proximity Read ↗

Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child.Semantic proximity Read ↗

Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility.Semantic proximity Read ↗

Neuraminidase Inhibitor-Resistant Recombinant A/Vietnam/1203/04 (H5N1) Influenza Viruses Retain Their Replication Efficiency and Pathogenicity In Vitro and In VivoSemantic proximity Read ↗

A reverse genetics study of resistance to neuraminidase inhibitors in an influenza A/H1N1 virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.