Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.

doi:10.1176/appi.ajp.2014.14030382

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Article

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.

The American journal of psychiatry - 1 Jun 2015

Ruggeri Barbara, Nymberg Charlotte, Vuoksimaa Eero, Lourdusamy Anbarasu, Wong Cybele P, Carvalho Fabiana M, Jia Tianye, Cattrell Anna, Macare Christine, Banaschewski Tobias, Barker Gareth J, Bokde Arun L W, Bromberg Uli, Büchel Christian, Conrod Patricia J, Fauth-Bühler Mira, Flor Herta, Frouin Vincent, Gallinat Jürgen, Garavan Hugh, Gowland Penny, Heinz Andreas, Ittermann Bernd, Martinot Jean-Luc, Nees Frauke, Pausova Zdenka, Paus Tomáš, Rietschel Marcella, Robbins Trevor, Smolka Michael N, Spanagel Rainer, Bakalkin Georgy, Mill Jonathan, Sommer Wolfgang H, Rose Richard J, Yan Jia, Aliev Fazil, Dick Danielle, Kaprio Jaakko, Desrivières Sylvane, Schumann Gunter

Abstract excerpt

OBJECTIVE: The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and psychiatric disorders, it is unclear how epigenetics, particularly DNA methylation, relate to brain function and behavior, including drinking behavior. METHOD: The authors...

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PMID: 25982659
DOI: 10.1176/appi.ajp.2014.14030382
PMCID: PMC4827248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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