Article
Association of CTLA-4 gene polymorphism with end-stage renal disease and renal allograft outcome.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Mar 2014
Misra Maneesh Kumar, Kapoor Rakesh, Pandey Shashi Kant, Sharma Raj Kumar, Agrawal Suraksha
Abstract excerpt
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is upregulated in effector-T-cells after activation that may alter signal transduction and subsequently cytokine production. The present study was designed to investigate the impact of CTLA-4+49 A>G (rs231775), -318 C>T (rs5742909), -658 C>T (rs11571317), -1147 C>T (rs16840252), -1661 A>G (rs4553808), +6230 A>G () SNPs, and microsatellite (AT)n repeat...