Article

Mechanism of ASF1 Inhibition by CDAN1

2024-08-08

Abstract excerpt

Codanin-1 (CDAN1) is an essential and ubiquitous protein named after congenital dyserythropoietic anemia type I (CDA-I), an autosomal recessive disease that manifests from mutations in the CDAN1 or CDIN1 ( CD AN1 interacting n uclease 1) gene. CDAN1 interacts with CDIN1 and the paralogous histone H3-H4 chaperones ASF1A ( A nti- S ilencing F unction 1A) and ASF1B, but its function remains unclear. Here, we b...

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Literature Corpus work: 541d2426-dede-55da-ae64-b7720db5c537
DOI: 10.1101/2024.08.08.607204

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