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Article

Phenotypic Knockout of CXCR4 Expression by a Novel Intrakine Mutant hSDF-1α/54/KDEL Inhibits Breast Cancer Metastasis.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Oct 2015

Chen Hong-Yuan, Clayman Eric S, Ma Wei-Feng

Abstract excerpt

Many malignant tumors express high levels of the chemokine receptor CXCR4, and the interaction between CXCR4 and its ligand, SDF-1, promotes migration, invasion, and metastasis of breast cancer cells. Therefore, blocking the interaction between CXCR4 and SDF-1 could alter the tumor's metastatic phenotype and control the development and progression of cancers. We used a cellular phenotypic knockout strategy and...

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Source

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Identifiers

PMID: 25978539
DOI: 10.1089/jir.2014.0141
PMCID: PMC4589268

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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