Article

Mutagenic and Genotoxic Effect of Hydroxyurea

2011-12-15

Abstract excerpt

The hydroxyurea, a cytotoxic drug, is the mainly available therapeutical strategy for the treatment of sickle cell disease. This study aimed to evaluate the mutagenic and genotoxic potential of the hydroxyurea through the Salmonella/Microsome assay and micronucleus test in peripheral blood of mice.The doses were evaluated at 29.25-468 μmol/plate in Salmonella/Microsome assay in presence and absence of metabolic ac...

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Literature Corpus work: 83ff4171-08b7-523b-9251-017022798da3
DOI: 10.59566/ijbs.2011.7263

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