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Article

Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development.

PloS one - 1 Jan 2016

Ferrés Millie A, Bianchi Diana W, Siegel Ashley E, Bronson Roderick T, Huggins Gordon S, Guedj Faycal

Abstract excerpt

BACKGROUND: The Ts1Cje model of Down syndrome is of particular interest for perinatal studies because affected males are fertile. This permits affected pups to be carried in wild-type females, which is similar to human pregnancies. Here we describe the early natural history and growth profiles of Ts1Cje embryos and neonates and determine if heart defects are present in this strain. METHODS: Pups were studied...

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Source

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Identifiers

PMID: 27930746
DOI: 10.1371/journal.pone.0168009
PMCID: PMC5145234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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