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Article

Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

PLoS genetics - 1 May 2015

Ng Ashley P, Hu Yifang, Metcalf Donald, Hyland Craig D, Ierino Helen, Phipson Belinda, Wu Di, Baldwin Tracey M, Kauppi Maria, Kiu Hiu, Di Rago Ladina, Hilton Douglas J, Smyth Gordon K, Alexander Warren S

Abstract excerpt

Down syndrome (DS), with trisomy of chromosome 21 (HSA21), is the commonest human aneuploidy. Pre-leukemic myeloproliferative changes in DS foetal livers precede the acquisition of GATA1 mutations, transient myeloproliferative disorder (DS-TMD) and acute megakaryocytic leukemia (DS-AMKL). Trisomy of the Erg gene is required for myeloproliferation in the Ts(1716)65Dn DS mouse model. We demonstrate here that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25973911
DOI: 10.1371/journal.pgen.1005211
PMCID: PMC4431731

Genes

ERG
GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.PMID 25973911Read ↗

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