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Article

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

9 Dec 2009

Abstract excerpt

Down syndrome is characterized by multiple phenotypic manifestations associated with trisomy of chromosome 21. The transient myeloproliferative disorder and acute megakaryocytic leukemia associated with Down syndrome are uniquely associated with mutations in the transcription factor GATA1; however, the identity of trisomic genes on chromosome 21 that predispose to these hematologic disorders remains unknown....

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PMID: 20007548
DOI: 10.1182/blood-2009-09-242107

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