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Article

IL-23/IL-17A Dysfunction Phenotypes Inform Possible Clinical Effects from Anti-IL-17A Therapies.

The Journal of investigative dermatology - 1 Aug 2015

Blauvelt Andrew, Lebwohl Mark G, Bissonnette Robert

Abstract excerpt

Biologics that neutralize specific cytokines have improved outcomes for several immune-mediated disorders but may also increase risks for particular side effects. This article postulates potential immunologic consequences of inhibiting components of the IL-23/T-helper cell 17 pathway-the target of next-generation biologics for treating psoriasis-based on clinical phenotypes of inherent or acquired deficiencies in...

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Identifiers

PMID: 25972190
DOI: 10.1038/jid.2015.144
PMCID: PMC4580732

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