Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions.

Immunity - 15 Dec 2015

Patel Dhavalkumar D, Kuchroo Vijay K

Abstract excerpt

The T helper 17 (Th17) cell pathway has been linked by genome-wide association studies to multiple autoimmune diseases. Identification of the genetic causes of primary immunodeficiency diseases revealed that Th17 cells are also critical in host immunity to mucocutaneous candida infections and Staphylococcus aureus. Therapeutic interventions with inhibitors of the different components of the pathway such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Diseases
Share to Autoimmunity
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Th17 Cells

Source

Identifiers

PMID: 26682981
DOI: 10.1016/j.immuni.2015.12.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions.PMID 26682981Read ↗

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.Semantic proximity Read ↗

Biological and clinical significance of T helper 17 cell deficiency: insight into monogenic defects.Semantic proximity Read ↗

IL-17 in the Pathogenesis of Disease: Good Intentions Gone AwrySemantic proximity Read ↗

The IL-17/IL-23 Axis and Its Genetic Contribution to Psoriatic Arthritis.Semantic proximity Read ↗

TH17 deficiency in human disease.Semantic proximity Read ↗

The IL-23/IL-17 pathway in human chronic inflammatory diseases—new insight from genetics and targeted therapiesSemantic proximity Read ↗

Th17 cells in immunity and autoimmunity.Semantic proximity Read ↗

Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasisSemantic proximity Read ↗

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis.Semantic proximity Read ↗

Chronic mucocutaneous candidiasis disease associated with inborn errors of IL‐17 immunitySemantic proximity Read ↗

Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infectionSemantic proximity Read ↗

IL-23/IL-17A Dysfunction Phenotypes Inform Possible Clinical Effects from Anti-IL-17A Therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.