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Exon Array Profiling Detects <i>EML4-ALK</i> Fusion in Breast, Colorectal, and Non–Small Cell Lung Cancers

8 Sept 2009

Abstract excerpt

The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene has been identified as an oncogene in a subset of non-small cell lung cancers (NSCLC). We used profiling of cancer genomes on an exon array to develop a novel computational method for the global search of gene rearrangements. This approach led to the detection of EML4-ALK fusion in breast and colorectal...

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PMID: 19737969
DOI: 10.1158/1541-7786.mcr-08-0522

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