Article
Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression.
Molecular cancer - 13 Jul 2010
Zhang Xuchao, Zhang Shirley, Yang Xuening, Yang Jinji, Zhou Qing, Yin Lucy, An Shejuan, Lin Jiaying, Chen Shiliang, Xie Zhi, Zhu Mike, Zhang Xiaolin, Wu Yi-long
Abstract excerpt
BACKGROUND: The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer. Fusion partners of ALK include NPM, EML4, TPM3, ATIC, TFG, CARS, and CLTC. Characterization of ALK fusio...
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