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Article

Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine.

Neurochemistry international - 1 Sept 2016

Iwamoto Hideki, Calcutt M Wade, Blakely Randy D

Abstract excerpt

The efficient import of choline into cholinergic nerve terminals by the presynaptic, high-affinity choline transporter (CHT, SLC5A7) dictates the capacity for acetylcholine (ACh) synthesis and release. Tissue levels of ACh are significantly reduced in mice heterozygous for a loss of function mutation in Slc5a7 (HET, CHT(+/-)), but significantly elevated in overexpressing, Slc5a7 BAC-transgenic mice (BAC). Since...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27013347
DOI: 10.1016/j.neuint.2016.03.012
PMCID: PMC4969175

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