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Culture-free whole genome sequencing of<i>Mycobacterium tuberculosis</i>using ligand-mediated bead enrichment method

2024-01-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Direct whole genome sequencing (WGS) of Mycobacterium tuberculosis ( Mtb ) can be used as a tool to study drug resistance, mixed infections, and within host diversity. However, WGS is challenging from clinical samples due to low number of bacilli against a high background. <h4>Methods</h4> We prospectively collected 34 samples (sputum, n=17; bronchoalveolar lavage, BAL, n=13 a...

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Literature Corpus work: a4653860-1e90-5da5-8584-5390e4038999
DOI: 10.1101/2024.01.23.24301340

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