How I treat T-cell acute lymphoblastic leukemia in adults.

doi:10.1182/blood-2014-10-551895

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Article

How I treat T-cell acute lymphoblastic leukemia in adults.

Blood - 13 Aug 2015

Litzow Mark R, Ferrando Adolfo A

Abstract excerpt

T-cell immunophenotype of acute lymphoblastic leukemia (T-ALL) is an uncommon aggressive leukemia that can present with leukemic and/or lymphomatous manifestations. Molecular studies are enhancing our understanding of the pathogenesis of T-ALL, and the discovery of activating mutations of NOTCH1 and FBXW7 in a majority of patients has been a seminal observation. The use of pediatric intensive combination...

Topics

Adolescent
Adult
Age Factors
Algorithms
Antineoplastic Combined Chemotherapy Protocols
Child
Disease-Free Survival
Drugs, Investigational
Female
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Mutation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
Young Adult

Source

Open in PubMed

Identifiers

PMID: 25966987
DOI: 10.1182/blood-2014-10-551895

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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