Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing Rare Variation in Complex Traits.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Kuchenbaecker Karoline, Appel Emil Vincent Rosenbaum

Abstract excerpt

While genome-wide association studies have been very successful in identifying associations of common genetic variants with many different traits, the rarer frequency spectrum of the genome has not yet been comprehensively explored. Technological developments increasingly lift restrictions to access rare genetic variation. Dense reference panels enable improved genotype imputation for rarer variants in studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Genetic Predisposition to Disease
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Genomics

Share to Genotyping Techniques

Share to Models, Statistical

Share to Multifactorial Inheritance

Source

Identifiers

PMID: 29876891
DOI: 10.1007/978-1-4939-7868-7_5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing Rare Variation in Complex Traits.PMID 29876891Read ↗

Identifying rare variants associated with complex traits via sequencing.Semantic proximity Read ↗

Discovery of rare variants for complex phenotypes.Semantic proximity Read ↗

In search of low-frequency and rare variants affecting complex traits.Semantic proximity Read ↗

Rare-variant genome-wide association studies: a new frontier in genetic analysis of complex traits.Semantic proximity Read ↗

Detecting rare variants.Semantic proximity Read ↗

Unique roles of rare variants in the genetics of complex diseases in humans.Semantic proximity Read ↗

How important are rare variants in common disease?Semantic proximity Read ↗

A general framework for detecting disease associations with rare variants in sequencing studies.Semantic proximity Read ↗

Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits.Semantic proximity Read ↗

Dynamic Bayesian testing of sets of variants in complex diseases.Semantic proximity Read ↗

Statistical analysis strategies for association studies involving rare variants.Semantic proximity Read ↗

Rare-variant association analysis: study designs and statistical tests.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.