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Article

The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice.

BioMed research international - 1 Jan 2015

Liang Jingsheng, Kazmierczak Katarzyna, Rojas Ana I, Wang Yingcai, Szczesna-Cordary Danuta

Abstract excerpt

We investigated the effect of the hypertrophic cardiomyopathy-linked R21C (arginine to cysteine) mutation in human cardiac troponin I (cTnI) on the contractile properties and myofilament protein phosphorylation in papillary muscle preparations from left (LV) and right (RV) ventricles of homozygous R21C(+/+) knock-in mice. The maximal steady-state force was significantly reduced in skinned papillary muscle strips...

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Source

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Identifiers

PMID: 25961037
DOI: 10.1155/2015/742536
PMCID: PMC4415466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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