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Article

Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2018

Arimura Takuro, Muchir Antoine, Kuwahara Masayoshi, Morimoto Sachio, Ishikawa Taisuke, Du Cheng-Kun, Zhan Dong-Yun, Nakao Shu, Machida Noboru, Tanaka Ryo, Yamane Yoshihisa, Hayashi Takeharu, Kimura Akinori

Abstract excerpt

Mutations in genes encoding components of the sarcomere cause cardiomyopathy, which is often associated with abnormal Ca2+ sensitivity of muscle contraction. We have previously shown that a heart-specific myosin light chain phosphatase small subunit (hHS-M21) increases the Ca2+ sensitivity of muscle contraction. The aim of the present study was to investigate the function of hHS-M21 in vivo and the causative role...

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Source

Identifiers

PMID: 29451818
DOI: 10.1152/ajpheart.00696.2017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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