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Article

High order gene-gene interactions in eight single nucleotide polymorphisms of renin-angiotensin system genes for hypertension association study.

BioMed research international - 1 Jan 2015

Yang Cheng-Hong, Lin Yu-Da, Wu Shyh-Jong, Chuang Li-Yeh, Chang Hsueh-Wei

Abstract excerpt

Several single nucleotide polymorphisms (SNPs) of renin-angiotensin system (RAS) genes are associated with hypertension (HT) but most of them are focusing on single locus effects. Here, we introduce an unbalanced function based on multifactor dimensionality reduction (MDR) for multiloci genotypes to detect high order gene-gene (SNP-SNP) interaction in unbalanced cases and controls of HT data. Eight SNPs of three...

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Share to Angiotensinogen
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Association Studies

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Share to Peptidyl-Dipeptidase A

Share to Receptor, Angiotensin, Type 1

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Source

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Identifiers

PMID: 25961019
DOI: 10.1155/2015/454091
PMCID: PMC4417588

Genes

ACE
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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