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Article

Gene-gene interactions in renin-angiotensin-aldosterone system contributes to end-stage renal disease susceptibility in a Han Chinese population.

TheScientificWorldJournal - 1 Jan 2014

Su Sui-Lung, Yang Hsin-Yi, Wu Chia-Chao, Lee Herng-Sheng, Lin Yuh-Feng, Hsu Chi-An, Lai Ching-Huang, Lin Chin, Kao Sen-Yeong, Lu Kuo-Cheng

Abstract excerpt

OBJECTIVE: In this study, we investigated whether RAAS gene single nucleotide polymorphisms (SNPs) and their interactions were associated with end-stage renal stage (ESRD). METHODOLOGY AND RESULTS: This was a case-control study for 647 ESRD cases and 644 controls. AGT (M235T (rs699) and T174M (rs4762)), AGTR1 (A1166C (rs5186) and C573T (rs5182)), ACE (I/D (rs1799752) and G2350A ()), and CYP11B2 C-344T...

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Share to Cytochrome P-450 CYP11B2
Share to Kidney Failure, Chronic
Share to Peptidyl-Dipeptidase A
Share to Protein Interaction Mapping
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Identifiers

PMID: 24977181
DOI: 10.1155/2014/169798
PMCID: PMC4003748

Genes

ACE
AGT
AGTR1

Variants

rs699
rs699
rs699
rs699
rs699

Provenance

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