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Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.

Developmental biology - 1 Aug 2015

Hare Lauren M, Schwarz Quenten, Wiszniak Sophie, Gurung Rajendra, Montgomery Karen G, Mitchell Christina A, Phillips Wayne A

Abstract excerpt

The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway regulates many cellular functions including proliferation, migration, survival and protein synthesis. Somatic mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K enzyme, are commonly associated with many human cancers as well as recently being implicated in human overgrowth syndromes. However, it is not clear if such mutations can...

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PMID: 25958091
DOI: 10.1016/j.ydbio.2015.04.022

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Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.PMID 25958091Read ↗

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