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Article

Regeneration of the aged thymus by a single transcription factor.

Development (Cambridge, England) - 1 Apr 2014

Bredenkamp Nicholas, Nowell Craig S, Blackburn C Clare

Abstract excerpt

Thymic involution is central to the decline in immune system function that occurs with age. By regenerating the thymus, it may therefore be possible to improve the ability of the aged immune system to respond to novel antigens. Recently, diminished expression of the thymic epithelial cell (TEC)-specific transcription factor Forkhead box N1 (FOXN1) has been implicated as a component of the mechanism regulating...

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Share to Cellular Microenvironment
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24715454
DOI: 10.1242/dev.103614
PMCID: PMC3978836

Genes

FOXN1
TEC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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