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Article

Arhgap29 Deficiency Directly Leads to Systemic and Craniofacial Skeletal Abnormalities

13 May 2025

Abstract excerpt

The Arhgap29 gene encodes Rho-GTPase-activating protein 29 (Arhgap29), which plays a crucial role in embryonic tissue development. Mutations in the Arhgap29 gene are significantly associated with non-syndromic cleft lip and palate (NSCL/P). Our study demonstrated that the deletion of Arhgap29 leads to syndromic cleft lip and palate (SCL/P) characteristics in mice, where, in addition to cleft palate, the mice...

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PMID: 40429791
DOI: 10.3390/ijms26104647

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