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Article

Common NOTCH3 Variants and Cerebral Small-Vessel Disease.

Stroke - 1 Jun 2015

Rutten-Jacobs Loes C A, Traylor Matthew, Adib-Samii Poneh, Thijs Vincent, Sudlow Cathie, Rothwell Peter M, Boncoraglio Giorgio, Dichgans Martin, Bevan Steve, Meschia James, Levi Christopher, Rost Natalia S, Rosand Jonathan, Hassan Ahamad, Markus Hugh S

Abstract excerpt

BACKGROUND AND PURPOSE: The most common monogenic cause of cerebral small-vessel disease is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, caused by NOTCH3 gene mutations. It has been hypothesized that more common variants in NOTCH3 may also contribute to the risk of sporadic small-vessel disease. Previously, 4 common variants (rs10404382, rs1043994, rs10423702, and...

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Source

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Identifiers

PMID: 25953367
DOI: 10.1161/STROKEAHA.114.008540
PMCID: PMC4442025

Genes

NOTCH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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