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Article

Cysteine-Altering NOTCH3 Variants Are a Risk Factor for Stroke in the Elderly Population.

Stroke - 1 Dec 2020

Hack Remco J, Rutten Julie W, Person Thomas N, Li Jiang, Khan Ayesha, Griessenauer Christoph J, Abedi Vida, Lesnik Oberstein Saskia A J, Zand Ramin

Abstract excerpt

BACKGROUND AND PURPOSE: Cysteine altering NOTCH3 variants, which have previously been exclusively associated with the rare hereditary small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, have a population frequency of 1:300 worldwide. Using a large population database, and taking genotype as a starting point, we aimed to determine whether individuals...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33161844
DOI: 10.1161/STROKEAHA.120.030343
PMCID: PMC7678653

Genes

NOTCH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Cysteine-Altering NOTCH3 Variants Are a Risk Factor for Stroke in the Elderly Population.PMID 33161844Read ↗

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NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants.Semantic proximity Read ↗

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<i>NOTCH3</i> variants are common in the general population and associated with stroke and vascular dementia: an analysis of 200,000 participantsSemantic proximity Read ↗

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Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants.Semantic proximity Read ↗

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