Article
Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease.
Neurology - 3 Mar 2015
Rannikmäe Kristiina, Davies Gail, Thomson Pippa A, Bevan Steve, Devan William J, Falcone Guido J, Traylor Matthew, Anderson Christopher D, Battey Thomas W K, Radmanesh Farid, Deka Ranjan, Woo Jessica G, Martin Lisa J, Jimenez-Conde Jordi, Selim Magdy, Brown Devin L, Silliman Scott L, Kidwell Chelsea S, Montaner Joan, Langefeld Carl D, Slowik Agnieszka, Hansen Björn M, Lindgren Arne G, Meschia James F, Fornage Myriam, Bis Joshua C, Debette Stéphanie, Ikram Mohammad A, Longstreth Will T, Schmidt Reinhold, Zhang Cathy R, Yang Qiong, Sharma Pankaj, Kittner Steven J, Mitchell Braxton D, Holliday Elizabeth G, Levi Christopher R, Attia John, Rothwell Peter M, Poole Deborah L, Boncoraglio Giorgio B, Psaty Bruce M, Malik Rainer, Rost Natalia, Worrall Bradford B, Dichgans Martin, Van Agtmael Tom, Woo Daniel, Markus Hugh S, Seshadri Sudha, Rosand Jonathan, Sudlow Cathie L M
Abstract excerpt
OBJECTIVES: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. METHODS: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage...
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