Article
Intrapatient Evolutionary Dynamics of Human Immunodeficiency Virus Type 1 in Individuals Undergoing Alternative Treatment Strategies with Reverse Transcriptase Inhibitors.
AIDS research and human retroviruses - 1 Jul 2015
Kayondo Jonathan K, Ndembi Nicaise, Parry Chris M, Cane Patricia A, Hué Stephane, Goodall Ruth, Dunn David T, Kaleebu Pontiano, Pillay Deenan, Mbisa Jean L
Abstract excerpt
Structured treatment interruption (STI) has been trialed as an alternative to lifelong antiretroviral therapy (ART). We retrospectively performed single genome sequencing of the HIV-1 pol region from three patients representing different scenarios. They were either failing on continuous therapy (CT-F), failing STI (STI-F), or suppressing on STI (STI-S). Over 460 genomes were generated from three to five different...
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