Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals.

Journal of virology - 1 Dec 2002

Martinez-Picado Javier, Frost Simon D W, Izquierdo Nuria, Morales-Lopetegi K, Marfil Silvia, Puig Teresa, Cabrera Cecilia, Clotet Bonaventura, Ruiz Lidia

Abstract excerpt

We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Viral
Share to Antiretroviral Therapy, Highly Active

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Base Sequence

Share to Evolution, Molecular

Share to Genes, env

Share to HIV Infections

Share to RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 12414975
DOI: 10.1128/jvi.76.23.12344-12348.2002
PMCID: PMC136865

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals.PMID 12414975Read ↗

Intrapatient Evolutionary Dynamics of Human Immunodeficiency Virus Type 1 in Individuals Undergoing Alternative Treatment Strategies with Reverse Transcriptase Inhibitors.Semantic proximity Read ↗

Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions.Semantic proximity Read ↗

Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART.Semantic proximity Read ↗

Lack of detectable human immunodeficiency virus type 1 superinfection during 1072 person-years of observation.Semantic proximity Read ↗

Persistence of drug-resistant HIV-1 after a structured treatment interruption and its impact on treatment response.Semantic proximity Read ↗

Evolution of total and integrated HIV-1 DNA and change in DNA sequences in patients with sustained plasma virus suppression.Semantic proximity Read ↗

Selection of drug-resistant HIV-1 mutants in response to repeated structured treatment interruptions.Semantic proximity Read ↗

Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Genetic Evolution in Patients with Prolonged Suppression of Plasma ViremiaSemantic proximity Read ↗

Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion modelSemantic proximity Read ↗

Evolution of Envelope Sequences of Human Immunodeficiency Virus Type 1 in Cellular Reservoirs in the Setting of Potent Antiviral TherapySemantic proximity Read ↗

Reactivation of ancestral strains of HIV-1 in the gp120 V3 env region in patients failing antiretroviral therapy and subjected to structured treatment interruption.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.