Article
Sequential filtering for clinically relevant variants as a method for clinical interpretation of whole exome sequencing findings in glioma.
BMC medical genomics - 23 Feb 2021
Ülgen Ege, Can Özge, Bilguvar Kaya, Akyerli Boylu Cemaliye, Kılıçturgay Yüksel Şirin, Erşen Danyeli Ayça, Sezerman O Uğur, Yakıcıer M Cengiz, Pamir M Necmettin, Özduman Koray
Abstract excerpt
BACKGROUND: In the clinical setting, workflows for analyzing individual genomics data should be both comprehensive and convenient for clinical interpretation. In an effort for comprehensiveness and practicality, we attempted to create a clinical individual whole exome sequencing (WES) analysis workflow, allowing identification of genomic alterations and presentation of neurooncologically-relevant findings....
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