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Article

Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity.

PloS one - 1 Jan 2012

Luo Wei, Su Jin, Zhang Xiao-Bing, Yang Zhi, Zhou Ming-Qian, Jiang Zhen-Min, Hao Pei-Pei, Liu Su-Dong, Wen Qian, Jin Qi, Ma Li

Abstract excerpt

BACKGROUND: The importance of CD4⁺ and CD8⁺ T cells in protection against tuberculosis (TB) is well known, however, the association between changes to the T cell repertoire and disease presentation has never been analyzed. Characterization of T-cells in TB patients in previous study only analyzed the TCR β chain and omitted analysis of the Vα family even though α chain also contribute to antigen recognition....

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Source

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Identifiers

PMID: 23110186
DOI: 10.1371/journal.pone.0048117
PMCID: PMC3482216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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