Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.

Human mutation - 1 Nov 2014

Walia Vijay, Prickett Todd D, Kim Jung-Sik, Gartner Jared J, Lin Jimmy C, Zhou Ming, Rosenberg Steven A, Elble Randolph C, Solomon David A, Waldman Todd, Samuels Yardena

Abstract excerpt

Protein tyrosine phosphatases (PTPs) tightly regulate tyrosine phosphorylation essential for cell growth, adhesion, migration, and survival. We performed a mutational analysis of the PTP gene family in cutaneous metastatic melanoma and identified 23 phosphatase genes harboring somatic mutations. Among these, receptor-type tyrosine-protein phosphatase delta (PTPRD) was one of the most highly mutated genes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Desmoplakins

Share to Intercellular Junctions

Share to Melanoma

Share to Protein Transport

Share to Receptor-Like Protein Tyrosine Phosphatases, Class 2

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 25113440
DOI: 10.1002/humu.22630
PMCID: PMC4394620

Genes

PTPRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.PMID 25113440Read ↗

Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene.Semantic proximity Read ↗

Melanoma and LEOPARD Syndrome: Understanding the Role of PTPN11 Mutations in Melanomagenesis.Semantic proximity Read ↗

Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.Semantic proximity Read ↗

Receptor tyrosine kinases and their activation in melanoma.Semantic proximity Read ↗

Tumor Protein D54 (TPD54) regulates intracellular protein trafficking, cellular function and disease progression in melanomaSemantic proximity Read ↗

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.Semantic proximity Read ↗

Genetic alterations of PTEN in human melanoma.Semantic proximity Read ↗

Malignant melanoma in a woman with LEOPARD syndrome: identification of a germline PTPN11 mutation and a somatic BRAF mutation.Semantic proximity Read ↗

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical ImplicationsSemantic proximity Read ↗

Association of PTPRT Mutations with Cancer Metastasis in Multiple Cancer Types.Semantic proximity Read ↗

Protein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior.Semantic proximity Read ↗

Mutational analysis of the tyrosine phosphatome in colorectal cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.