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Article

Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma

6 Jan 2024

Abstract excerpt

Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease prognosis. PLK1 has been shown to interact with NUMB, a NOTCH antagonist. However, the exact role of PLK1, NUMB, and NOTCH signaling in epithelial-mesenchymal transition (EMT) in melanoma progression is unclear. In this study, Affymetrix microarray analysis was performed to...

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PMID: 38184733
DOI: 10.1038/s41698-023-00493-7

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Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanomaPMID 38184733Read ↗

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