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Article

Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.

Diabetologia - 1 Sept 2011

Jamieson P M, Cleasby M E, Kuperman Y, Morton N M, Kelly P A T, Brownstein D G, Mustard K J, Vaughan J M, Carter R N, Hahn C N, Hardie D G, Seckl J R, Chen A, Vale W W

Abstract excerpt

AIMS/HYPOTHESIS: Urocortins are the endogenous ligands for the corticotropin-releasing factor receptor type 2 (CRFR2), which is implicated in regulating energy balance and/or glucose metabolism. We determined the effects of chronic CRFR2 activation on metabolism in vivo, by generating and phenotyping transgenic mice overproducing the specific CRFR2 ligand urocortin 3. METHODS: Body composition, glucose...

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Identifiers

PMID: 21667214
DOI: 10.1007/s00125-011-2205-6
PMCID: PMC3149678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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