Article
The epithelial sodium channel: from molecule to disease.
Reviews of physiology, biochemistry and pharmacology - 1 Jan 2004
Schild L
Abstract excerpt
Genetic analysis has demonstrated that Na absorption in the aldosterone-sensitive distal nephron (ASDN) critically determines extracellular blood volume and blood pressure variations. The epithelial sodium channel (ENaC) represents the main transport pathway for Na+ absorption in the ASDN, in particular in the connecting tubule (CNT), which shows the highest capacity for ENaC-mediated Na+ absorption....
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