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Methylenetetrahydrofolate reductase gene haplotypes affect toxicity during maintenance therapy for childhood acute lymphoblastic leukemia in Japanese patients.

Leukemia & lymphoma - 1 May 2014

Tanaka Yoichi, Manabe Atsushi, Nakadate Hisaya, Kondoh Kensuke, Nakamura Kozue, Koh Katsuyoshi, Kikuchi Akira, Komiyama Takako

Abstract excerpt

Abstract The aim of this study was to investigate the influence of daily 6-mercaptopurine (6-MP) and low-dose weekly methotrexate (MTX) combination treatment and methylenetetrahydrofolate reductase (MTHFR) haplotypes on toxicity during maintenance therapy in Japanese childhood acute lymphoblastic leukemia (ALL). We retrospectively analyzed the MTHFR C677T and A1298C polymorphisms and influence of haplotypes on...

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PMID: 23865834
DOI: 10.3109/10428194.2013.825902

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MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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