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Article

Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation

4 May 2015

Abstract excerpt

The forced reduction of global DNA methylation suppresses tumor development in several cancer models in vivo. Nevertheless, the mechanisms underlying these suppressive effects remain unclear. In this report, we describe our findings showing that a genome-wide reduction in the DNA methylation levels induces cellular differentiation in association with decreased cell proliferation in Apc (Min/+) mouse colon tumor...

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PMID: 25939752
DOI: 10.1093/carcin/bgv060

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