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Article

A cautionary note on the impact of protocol changes for genome-wide association SNP × SNP interaction studies: an example on ankylosing spondylitis.

Human genetics - 1 Jul 2015

Bessonov Kyrylo, Gusareva Elena S, Van Steen Kristel

Abstract excerpt

Genome-wide association interaction (GWAI) studies have increased in popularity. Yet to date, no standard protocol exists. In practice, any GWAI workflow involves making choices about quality control strategy, SNP filtering, linkage disequilibrium (LD) pruning, analytic tool to model or to test for genetic interactions. Each of these can have an impact on the final epistasis findings and may affect their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25939665
DOI: 10.1007/s00439-015-1560-7

Genes

ERAP1
MAGI3

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