Article
Biological consequences of dosage dependent gene regulatory systems.
Biochimica et biophysica acta - 1 Jan 2000
Birchler James A, Yao Hong, Chudalayandi Siva
Abstract excerpt
Chromatin and gene regulatory molecules tend to operate in multisubunit complexes in the process of controlling gene expression. Accumulating evidence suggests that varying the amount of any one member of such complexes will affect the function of the whole via the kinetics of assembly and other actions. In effect, they exhibit a "balance" among themselves in terms of the activity of the whole. When this fact is...
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