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Article

Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines.

Proceedings of the National Academy of Sciences of the United States of America - 11 Sept 2012

Birchler James A, Veitia Reiner A

Abstract excerpt

We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after partial or whole-genome duplication. Gene balance effects are hypothesized to result from stoichiometric differences among members of macromolecular complexes, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22908297
DOI: 10.1073/pnas.1207726109
PMCID: PMC3443177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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