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Article

Low-frequency coding variants at 6p21.33 and 20q11.21 are associated with lung cancer risk in Chinese populations.

American journal of human genetics - 7 May 2015

Jin Guangfu, Zhu Meng, Yin Rong, Shen Wei, Liu Jia, Sun Jie, Wang Cheng, Dai Juncheng, Ma Hongxia, Wu Chen, Yin Zhihua, Huang Jiaqi, Higgs Brandon W, Xu Lin, Yao Yihong, Christiani David C, Amos Christopher I, Hu Zhibin, Zhou Baosen, Shi Yongyong, Lin Dongxin, Shen Hongbing

Abstract excerpt

Genome-wide association studies have successfully identified a subset of common variants associated with lung cancer risk. However, these variants explain only a fraction of lung cancer heritability. It has been proposed that low-frequency or rare variants might have strong effects and contribute to the missing heritability. To assess the role of low-frequency or rare variants in lung cancer development, we...

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Source

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Identifiers

PMID: 25937444
DOI: 10.1016/j.ajhg.2015.03.009
PMCID: PMC4570553

Genes

BPIFB1
FKBPL

Variants

rs9469031
rs6141383
rs200847762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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