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Article

Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer

29 Nov 2017

Abstract excerpt

The ataxia-telangiectasia mutated (ATM) protein kinase has been extensively studied for its role in the DNA damage response and its association with the disease ataxia telangiectasia. There is increasing evidence that ATM also plays an important role in other cellular processes, including carbon metabolism. Carbon metabolism is highly dysregulated in cancer due to the increased need for cellular biomass. A number...

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Identifiers

PMID: 29238697
DOI: 10.3389/fonc.2017.00291

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