Article
PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015
Park Hyo Jin, Park Joon Seok, Jeong Yun Hee, Son Jimin, Ban Young Ho, Lee Byoung-Hee, Chen Lieping, Chang Jun, Chung Doo Hyun, Choi Inhak, Ha Sang-Jun
Abstract excerpt
Regulatory T (Treg) cells act as terminators of T cell immuniy during acute phase of viral infection; however, their role and suppressive mechanism in chronic viral infection are not completely understood. In this study, we compared the phenotype and function of Treg cells during acute or chronic...
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