Article
Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection.
Immunity - 1 Mar 2004
Dittmer Ulf, He Hong, Messer Ronald J, Schimmer Simone, Olbrich Anke R M, Ohlen Claes, Greenberg Philip D, Stromnes Ingunn M, Iwashiro Michihiro, Sakaguchi Shimon, Evans Leonard H, Peterson Karin E, Yang Guojun, Hasenkrug Kim J
Abstract excerpt
The establishment of viral persistence generally requires evasion of the host CD8(+) T cell response. Here we describe a form of evasion wherein the CD8(+) T cells are fully capable of recognizing their cognate antigen but their effector functions are suppressed by regulatory T cells. Virus-speci...
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