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Article

Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection.

Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2013

Holderried Tobias A W, Lang Philipp A, Kim Hye-Jung, Cantor Harvey

Abstract excerpt

The immunological interactions that regulate the T-cell response to chronic viral infection are insufficiently understood. Here we study a cellular interaction that may enhance the antiviral immune response and constrain immunopathology. We analyze the contribution of Qa-1-restricted CD8(+) regul...

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Share to Adoptive Transfer
Share to CD8-Positive T-Lymphocytes
Share to DNA Virus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Immunity, Cellular

Share to Lymphocytic choriomeningitis virus

Share to Statistics, Nonparametric

Share to T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 24324159
DOI: 10.1073/pnas.1320999110
PMCID: PMC3876206

Genes

KLRG1
LAG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24324159-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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